Patient Resources

Closely monitor infants during the first 2 weeks of SYNTHROID therapy for cardiac overload and arrhythmias. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Seizures have been reported rarely with the institution of levothyroxine therapy.

Synthroid side effects

• The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3.
• Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration.
• Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive SYNTHROID therapy.
• Administer SYNTHROID as a single daily dose, on an empty stomach, one-half to one hour before breakfast.
• Reduce the SYNTHROID dosage or discontinue temporarily if signs or symptoms of overdosage occur.
• Dosage titration is based on serum TSH or free-T4 see Important Considerations For Dosing.

The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as described in Table 2. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free- T4 until the patient is euthyroid see Important Considerations For Dosing. For secondary or synthroid hipotireoidismo tertiary hypothyroidism, serum TSH is not a reliable measure of SYNTHROID dosage adequacy and should not be used to monitor therapy.

• The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
• This is not a complete list of side effects and others may occur.
• Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter.
• Seizures occurred in a 3-yearold child ingesting 3.6 mg of levothyroxine.
• Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
• In order for Synthroid to be effective, it should always be taken the same way every day.

Dosage Forms And Strengths

• And even the way you take Synthroid can affect how much medicine your body is getting.
• It may take several weeks before your body starts to respond to Synthroid.
• HypothyroidismSYNTHROID® (levothyroxine sodium) tablets, for oral use is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.
• SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.
• The major pathway of thyroid hormone metabolism is through sequential deiodination.

Monitor patients receiving concomitant SYNTHROID and sympathomimetic agents for signs and symptoms of coronary insufficiency. Consider changes in TBG concentration when interpreting T4 and T3 values. Measure and evaluate unbound (free) hormone and/or determine the free-T4 index (FT4I) in this circumstance. Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration. Nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, androgens, and corticosteroids decrease TBG concentration.

We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. Administer SYNTHROID as a single daily dose, on an empty stomach, one-half to one hour before breakfast. Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain. Get medical help right away, if you have any of the symptoms listed above. Who are otherwise healthy non-elderly and have been hypothyroid for a few months.

Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

Closely monitor coagulation tests to permit appropriate and timely dosage adjustments. Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation. Persistent clinical and laboratory evidence of hypothyroidism despite an apparent adequate replacement dose of SYNTHROID may be evidence of inadequate absorption, poor compliance, drug interactions, or a combination of these factors.

Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension. Doctors often may have to slowly increase the dose; patients should not increase or decrease this medication themselves. Because some preparations of the drug may contain iodine or lactose, patients should tell their doctors about such allergies or reactions to these components.

SYNTHROID is not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients, as there are no clinical benefits and overtreatment with SYNTHROID may induce hyperthyroidism. The Before Breakfast Club is a program designed to help support your patients on SYNTHROID therapy. After joining, patients will receive exclusive benefits including savings, tips, and tools to help your patients make the most of their SYNTHROID treatment.

In addition, many drugs and foods affect T4 absorption see DRUG INTERACTIONS. SYNTHROID is indicated in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. HypothyroidismSYNTHROID® (levothyroxine sodium) tablets, for oral use is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma.

The major pathway of thyroid hormone metabolism is through sequential deiodination. Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination. The liver is the major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including the kidney and other tissues. Approximately 80% of the daily dose of T4 is deiodinated to yield equal amounts of T3 and reverse T3 (rT3).